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10 questions in session · Endocrine
Q1
Endocrine Hard Confusion, Hypoglycaemia, Emergency
An 80-year-old woman with Type 2 Diabetes is found confused and sweaty by her carers. A capillary blood glucose measurement is 2.4 mmol/L. She is conscious but unable to swallow safely. What is the most appropriate first-line treatment in this community setting?
Q2
Endocrine Medium Abdominal pain, Diabetic ketoacidosis, Clinical assessment
A 19-year-old man with Type 1 Diabetes is brought to the ED with abdominal pain and vomiting. He is tachycardic, tachypnoeic, and his breath has a fruity odour. Investigations show: capillary glucose 22 mmol/L, blood ketones 4.2 mmol/L, and venous pH 7.15. Following initial fluid resuscitation, an insulin infusion is started. Which monitoring parameter is the primary indicator of the resolution of DKA?
Q3
Endocrine Medium Polyuria, Diabetes insipidus, Diagnosis
A 25-year-old man presents with polyuria and polydipsia. A water deprivation test is performed. After 8 hours of deprivation, his urine osmolality remains low at 200 mOsm/kg. Following administration of Desmopressin, his urine osmolality increases to 750 mOsm/kg. What is the diagnosis?
Q4
Endocrine Easy Hypertension, Conn's syndrome, Investigation
A 44-year-old man is investigated for hypertension that has remained poorly controlled despite being on Amlodipine and Ramipril. His potassium is 3.1 mmol/L. His Aldosterone-to-Renin Ratio (ARR) is significantly elevated. What is the next most appropriate imaging step to localise the lesion?
Q5
Endocrine Medium Hypertension, Phaeochromocytoma, Prescribing
A 40-year-old man presents with episodic headaches, palpitations, and diaphoresis. During an episode in the clinic, his blood pressure is 210/115 mmHg. A 24-hour urinary collection shows elevated metanephrines. He is scheduled for surgical resection. Which class of medication must be initiated first to prepare him for surgery?
Q6
Endocrine Medium Weight gain, Cushing's syndrome, Diagnosis
A 50-year-old woman presents with proximal muscle weakness, central obesity, and purple striae on her abdomen. An overnight 1mg dexamethasone suppression test shows a morning cortisol of 150 nmol/L (normal <50). Her ACTH is found to be suppressed (<5 pg/mL). What is the most likely source of her symptoms?
Q7
Endocrine Easy Fatigue, Addison's disease, Investigation
A 32-year-old woman presents with extreme fatigue, weight loss, and hyperpigmentation of her palmar creases. Her blood pressure is 95/60 mmHg. Laboratory results show sodium 128 mmol/L and potassium 5.6 mmol/L. What is the most appropriate definitive diagnostic test for this patient?
Q8
Endocrine Easy Sore throat, Graves' disease, Prescribing
A 45-year-old woman is diagnosed with hyperthyroidism based on a suppressed TSH and elevated free T4. She has a smooth goitre and mild exophthalmos. She is started on Carbimazole. Which side effect must she be specifically counselled to report immediately if she develops a sore throat or fever?
Q9
Endocrine Medium Fatigue, Hypothyroidism, Prescribing
A 78-year-old man with a history of ischaemic heart disease is diagnosed with primary hypothyroidism (TSH 18 mU/L, Free T4 8 pmol/L). He is to be started on Levothyroxine. What is the recommended starting dose for this patient?
Q10
Endocrine Easy Renal colic, Primary hyperparathyroidism, Diagnosis
A 64-year-old woman presents to her GP complaining of recurrent kidney stones and low mood. Blood tests show an albumin-adjusted calcium of 2.85 mmol/L (2.20–2.60) and a parathyroid hormone (PTH) level of 11.2 pmol/L (1.6–6.9). Her phosphate is low-normal. What is the most likely underlying diagnosis?